Structure of the zinc transporter yiip
WebApr 29, 2009 · Structural basis for autoregulation of the zinc transporter YiiP. Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-A resolution … WebJan 22, 2013 · YiiP is a dimeric Zn 2+ /H + antiporter from Escherichia coli belonging to the cation diffusion facilitator family. We used cryoelectron microscopy to determine a 13-Å resolution structure of a YiiP homolog …
Structure of the zinc transporter yiip
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WebOct 2, 2024 · The Zrt-irt-like proteins (ZIPs) and Zn transporters (ZnTs) are the two major families of Zn transport proteins involved in Zn transport in intestinal epithelial cells (Bin et al., 2024). There are... WebFeb 23, 2024 · YiiP is a prokaryotic Zn 2+ /H + antiporter that serves as a model for the Cation Diffusion Facilitator (CDF) superfamily, members of which are generally …
WebStructural Basis for Auto-regulation of the Zinc Transporter YiiP - PMC Published in final edited form as: Escherichia coli mutant strain more tolerant to iron exposure 29, but whether YiiP is a bona fide ferrous iron efflux facilitator (FieF) remains controversial 14. Figure 2 … WebJul 24, 2012 · Inward-Facing Conformation of the Zinc Transporter YiiP revealed by Cryo-electron Microscopy. ... We used cryoelectron microscopy to determine a 13-Å resolution structure of a YiiP homolog from Shewanella oneidensis within a lipid bilayer in the absence of Zn(2+). Starting from the X-ray structure in the presence of Zn(2+), we used molecular ...
WebStructural basis for autoregulation of the zinc transporter YiiP Min Lu, Jin Chai & Dax Fu from Escherichia coli reveals a richly charged dimer interface stabilized by zinc binding. WebBackground: YiiP is a bacterial zinc-for-proton antiporter belonging to the cation diffusion facilitator family. The zinc(II) ions are transported across the cell membrane, from the cytosol to the extracellular space. Methods: We performed atomistic molecular dynamics simulations of the YiiP dimer with zinc(II) ions in solution to elucidate how the metal ions …
WebJun 27, 2007 · YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in …
WebFeb 28, 2024 · The preference for the IF state even with the presence of the Zn 2+ ion maybe be the result of the unique helical crystalline structure adopted by soYiiP and used in the EM studies. 10 The I Z complex is a Zn 2+ loaded YiiP embedded in a DOPC bilayer, comprised of eight zinc ions located at all three zinc-binding sites (i.e., ZnA, ZnB, and ZnC). the boring company summer internshipWebAbstract. Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-resolution structure of the zinc transporter YiiP from Escherichia coli reveals a richly … the boring company tickerWebAug 23, 2007 · YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in … the boring company publicly tradedWebFeb 28, 2024 · YiiP is a secondary transporter that couples Zn ²⁺ transport to the proton motive force. Structural studies of YiiP from prokaryotes as well as Znt8 from humans revealed three different Zn ² ... the boring conferenceWebMechanism of Zinc Transport through the Zinc Transporter YiiP. Gaurav Sharma and Kenneth M. Merz* J. Chem. Theory Comput. 2024, 18, 4, 2556-2568. Publication Date (Web): February 28, 2024. ... Insights into the Structure–Property Relationships of Ionic Liquids with a Triarylmethyl Moiety. Grace I. Anderson, David Hardy, Patrick C. Hillesheim the boring company twitterWebThe means by which Ca 2+ store depletion evokes the opening of store-operated Ca 2+ channels (SOCs) in the plasma membrane of excitable and non-excitable cells has been a longstanding mystery. Indirect evidence has supported local interactions between the ER and SOCs as well as long-range interactions mediated through a diffusible activator. the boring company storeWebJul 29, 2016 · Here, we generated a predicted structure of SLC30A10, based on the structure of the bacterial zinc transporter YiiP, and performed functional studies. In YiiP, side chains of residues Asp-45 and Asp-49 in … the boring company texas