WebThe proportions of IgA polymers and IgA2 in serum are unlinked parameters, suggesting that both do not necessarily represent mucosal contributions to blood IgA. AbstractThe serum IgA in young infants (6–240 days old) comprised a much larger proportion ( $$\bar X$$ =36%; range, 7.5–72%) of polymeric IgA than in normal adults ( $$\bar X$$ =13%; range, … WebMucosal J (joining) chain-expressing IgA immunocytes produce dimeric IgA that is actively transported by the epithelial polymeric Ig receptor (pIgR) to exocrine secretions. Release …
Structure and function relationships in IgA Mucosal Immunology
WebFeb 25, 2024 · Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the epithelium and subsequent secretion into mucosal fluids are mediated … The high prevalence of IgA in mucosal areas is a result of a cooperation between plasma cells that produce polymeric IgA (pIgA), and mucosal epithelial cells that express polymeric immunoglobulin receptor (pIgR). Polymeric IgA (mainly the secretory dimer) is produced by plasma cells in the lamina … See more Immunoglobulin A (Ig A, also referred to as sIgA in its secretory form) is an antibody that plays a role in the immune function of mucous membranes. The amount of IgA produced in association with mucosal membranes is … See more IgA1 vs. IgA2 IgA exists in two isotypes, IgA1 and IgA2. They are both heavily glycosylated proteins. While IgA1 … See more Genetic Decreased or absent IgA due to an inherited inability to produce IgA is termed selective IgA deficiency and can produce a clinically significant See more Serum IgA In the blood, IgA interacts with an Fc receptor called FcαRI (or CD89), which is expressed on … See more • List of target antigens in pemphigus • TGF beta See more • Immunoglobulin+A at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Herich, R. (2024). "Is the role of IgA in local immunity completely known?". Food and … See more cylindrical manhole
Relationship of the quaternary structure of human secretory IgA to ...
WebApr 5, 2024 · 聚合IgA(polymeric IgA,pIgA)主要由黏膜相关淋巴组织(mucosal-associated lymphoid tissue,MALT)中的浆细胞产生。在与聚合Ig 受体结合后,pIgA 通过黏膜上皮进入分泌物。在管腔表面,该受体随后被切割形成稳定的多肽链,它与pIgA 结合形成分泌型IgA(sIgA)。 WebSep 28, 2011 · The polymeric immunoglobulin receptor (pIgR) has the dual role of transporting locally produced dimeric IgA across mucosal epithelia, and serving as the … WebThe proportions of IgA polymers and IgA2 in serum are unlinked parameters, suggesting that both do not necessarily represent mucosal contributions to blood IgA. AbstractThe serum … cylindrical measuring cylinder