WebHIGD1A is also involved in mitochondrial fusion by regulating OPA1 activity. Its inhibition of the cleavage of OPA1 preserves mitochondrial membrane potential, protects against apoptosis, and maintains ATP levels. Its role in mitochondrial fusion also influences downstream processes such as mtDNA synthesis, cell growth, and cristae organization. Web4 de jan. de 2024 · ARID1A has been discovered as a potential cancer biomarker. But its role in hepatocellular carcinoma (HCC) is subject to considerable dispute. Methods. The …
HIGD2A silencing impairs hepatocellular carcinoma growth via …
Web7 de ago. de 2024 · 缺氧诱导因子1α(HIF-1α)是介导细胞参与缺氧反应的重要转录调控因子,可上调一系列与肝纤维化相关基因的表达促进肝纤维化。 众所周知,肝星状细胞(HSC)的激活在肝纤维化的发展过程中起核心作用,研究表明HIF-1α可激活HSC,促进肝纤维化的发生发展。 此外,Copple等敲除HIF-1α后发现肝纤维化程度明显减轻。 上述 … Web30 de abr. de 2013 · HIGD1A is a ∼10 kDa mitochondrial inner membrane protein with adaptive functions during glucose deprivation [40], and promotes normal mitochondrial function via modulation of the mitochondrial γ-secretase complex [41]. The survival effect of HIGD1A is dependent on the level of HIGD1A expression [42]. how to see someones instagram when private
A global view of hepatocellular carcinoma: trends, risk
WebHepatocellular carcinoma (HCC), the most common primary liver cancer, remains a deadly cancer, with an incidence that has tripled in the United States since 1980. In recent … Web12 de abr. de 2024 · HIGD2A was overexpressed in HCC tissues and cell lines and was associated with a worse prognosis. Silencing HIGD2A expression significantly attenuated cell proliferation and migration, caused S-phase cell cycle arrest, and decreased tumor formation in nude mice. Web21 de mar. de 2024 · HIGD1A (HIG1 Hypoxia Inducible Domain Family Member 1A) is a Protein Coding gene. Diseases associated with HIGD1A include Cecum … how to see someone on fb that blocked you