Cytokeratin 19 protein
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate filaments, which help cells resist mechanical stress. Expression of these cytokeratins within epithelial cells is largely specific to particular organs or tissues. Thus they are used clinically to identify the cell of origin of various human tumors. WebFeb 15, 2024 · Cytokeratin 18 (CK18) belongs to the cytokeratin acidic type I group (CK9-CK12) and is encoded by a gene located at chromosome 12q13 (Moll et al. 1982; …
Cytokeratin 19 protein
Did you know?
Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. See more Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin. See more Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into … See more Keratin 19 has been shown to interact with Pinin. See more KRT19 is also known as Cyfra 21-1. Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes See more • Otsuka Y, Ichikawa Y, Kunisaki C, Matsuda G, Akiyama H, Nomura M, Togo S, Hayashizaki Y, Shimada H (2007). "Correlating purity by microdissection with gene expression in … See more
WebApr 14, 2024 · Increased cytokeratin-19 expression, reflecting a more advanced ductular reaction, is associated with rapid fibrosis progression in cholestatic liver disorders . ... M30 detects only caspase-cleaved fragments of cytokeratin-18 but not the native protein; thus, the presence of CK-18 in plasma reflects epithelial cell apoptosis. The limit of ... WebRecombinant Human Cytokeratin 19 protein (denatured) is an Escherichia coli Full length protein 1 to 400 aa range, > 90% purity and validated in SDS-PAGE. Recombinant …
WebCytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. WebDescription Product name Recombinant Human Cytokeratin 19 protein (denatured) Purity > 90 % SDS-PAGE. Expression system Escherichia coli Accession P08727 Protein length Full length protein Animal free No Nature Recombinant Species Human Sequence
WebCytokeratin 19, also known as KRT19, is an intermediate filament protein that gives structure to epithelial cells. Beyond its role as a structural protein, KRT19 is involved in cell signaling pathways including Wnt/Notch and EGR1/PTEN/AKT, although the response to altered expression is highly cell-type dependent.
WebCytokeratin 19 Product Code: NCL-L-CK19 Intended Use For in vitro diagnostic use. NCL-L-CK19 is intended for the qualitative identification by light microscopy of human cytokeratin 19 intermediate filament protein in paraffin sections. The clinical interpretation of any staining or its absence should be complemented by morphological studies using eagles club naugatuck ctWebCytokeratin 19, also known as keratin 19, is a type I intermediate filament protein with a molecular weight of approximately 40-44 kD. Cytokeratin 19 is a heterotetramer composed of two type I and two type II keratin subunits. Unlike other cytokeratins, cytokeratin 19 lacks a C-terminal non-helical extension. eagles club orting waWebMay 9, 2024 · Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, … csm14mb chop sawWebCytokeratin 19, also known as keratin 19, is a type I intermediate filament protein with a molecular weight of approximately 40-44 kD. Cytokeratin 19 is a heterotetramer … csm2002fe downloadWeb65 results for Cytokeratin 19 Sort by. Clear all Done. Filters. ... ELISA and Matched Antibody Pair Kits (4) Proteins and Peptides (1) Target / Protein Clear. Cytokeratin 19 (48) Cytokeratin (8) Cytokeratin 10 (4) Cytokeratin 20 (4) Cytokeratin 8 + 18 + 19 (1) Applications Clear. csm 18icWebMar 21, 2024 · KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Breast Cancer and Eccrine Porocarcinoma . Among its related pathways are Keratinization and Nervous system … csm 2017 pediatric handoutsWebCytokeratin 19, also known as keratin 19, is a type I intermediate filament protein with a molecular weight of approximately 40-44 kD. Cytokeratin 19 is a heterotetramer composed of two type I and two type II keratin subunits. Unlike other cytokeratins, cytokeratin 19 lacks a C-terminal non-helical extension. eagles club nags head