Cytoglobin function
WebAbstact. Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region … WebMay 20, 2013 · Background. Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. Methods. We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 …
Cytoglobin function
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WebMost known globins fulfill respiratory functions, supplying the cell with adequate amounts of O 2 for aerobic energy production via the respiratory chain in the mitochondria [5–7]. ... [16–18] and is now officially named cytoglobin (Cygb), based on its widespread expression in many mammalian tissues and organs. WebConclusions: Downregulation of CYGB by the TGF-β1/pSMAD2/SP3-M1 pathway brings about •OH-dependent oxidative DNA damage in activated hepatic stellate cells from patients with NASH. Lay summary: Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species and protects cells from oxidative DNA damage.
WebApr 27, 2016 · Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons. Here we provide, using immunohistochemistry, a … WebCytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions Cytoglobin (Cygb) is a novel member of the vertebrate globin superfamily. Although it is expressed in splanchnic fibroblasts of various organs, details of its function remain unknown.
WebSep 15, 2008 · Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region … WebBackground: Cytoglobin plays cytoprotective roles under hypoxic/ischemic conditions, but the mechanisms remain unclear.Results: Cytoglobin functions as a nitrite reductase leading to NO generation and soluble …
WebCytoglobin consumes NO through its dioxygenase activity, whereby oxycytoglobin (reduced cytoglobin with O2 bound) reacts with NO, resulting in the oxidation of the heme group and formation of nitrate as a byproduct. From: Nitric Oxide (Third Edition), 2024 Related terms: Fibroblast Myoglobin Nitric Oxide Nitrite Reductase Myofibroblast Neuroglobin
WebAug 26, 2003 · Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. Cytoglobin is a recently discovered hemeprotein belonging to the globin superfamily together with hemoglobin, myoglobin and neuroglobin. Although distributed in almost all human tissues, cytoglobin has not been ascribed a … fitz and floyd imperial fernWebMar 31, 2024 · cytoglobin antioxidant function relied on the same reductive pathway and did not recruit and was not reliant on alternate pathways. The ability of cytoglobin to … can i have a ccj removedWebCytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O 2 reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb)). While Cgb is expressed in various tissues, its physiological role is not clearly understood. Here, the X-ray crystal structure of wild type … fitz and floyd holiday solsticefitz and floyd huntingtonWebThe globin family includes eight different types of globins, but the best described and characterized in vertebrates are hemoglobin (Hb), myoglobin (Mb), cytoglobin (Cygb), … can i have a cat scan if i have a pacemakerWebMay 16, 2024 · Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress ( Trent and Hargrove, 2002 ). Cloning and Expression fitz and floyd hummingbird teapotWebApr 10, 2024 · Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates... fitz and floyd led candle set