Ctsk macrophage
WebThe activation of NFATc1, the master of osteoclastogenic transcription factor, directly regulates the induction of many osteoclastic genes, including cathepsin K (CtsK), matrix me- talloproteinase-9 (MMP-9), osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphatase (TRAP), and dendritic cell–specific transmembrane protein ... WebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with …
Ctsk macrophage
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Web1 day ago · RAW264.7 macrophages, used as a preosteoclast model, were incubated in 89% DMEM medium until they reached 80% confluence, and were then cocultured for 10 days with T cells extracted from the ... WebLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen. Cathepsin K regulates the tumor growth and metastasis …
WebJul 13, 2024 · Cathepsin K (Ctsk) is a cysteine protease of the papain superfamily initially identified in differentiated osteoclasts; it plays a critical role in degrading the bone matrix. However, subsequent in vivo and in vitro studies based on animal models elucidate novel subpopulations of Ctsk-expressing cells, which display markers and properties of … WebJun 5, 2024 · CTSK and MMP9 transcripts have also been found to be part of a macrophage multinucleation network in the rat (Kang et al., 2014). In addition, MGCs have been shown to express TRAP ( Park et al., 2012 ), suggesting that phenotypic markers of cell multinucleation are shared by MGCs and osteoclasts.
WebContribute to zhengxj1/Seurat development by creating an account on GitHub. WebMar 29, 2024 · CTSK cathepsin K Gene ID: 1513, updated on 29-Mar-2024 Gene type: protein coding Also known as: ... Cathepsin K regulates the tumor growth and metastasis by IL-17/CTSK/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer. Wu N, Wang Y, Wang K, Zhong B, Liao Y, Liang J, Jiang NWu N, et al. …
WebMay 21, 2012 · CTSK KO macrophages are less invasive than WT cells. The ability to invade surrounding matrix is another key factor affecting macrophage infiltration into the …
WebOct 1, 2001 · Cathepsin K (Ctsk) produced by osteoclasts, Cathepsin B (Ctsb) produced by septoclasts, macrophages, and osteoclasts, and immunostaining for the pan-macrophage marker F4/80 were performed (7,(51 ... reading walk in health centreWebApr 13, 2024 · The TRAP, CTSK, and MMP-9 proteins are abundantly expressed in mature osteoclasts, and involved in the osteoclast functions of the bone resorption. A murine macrophage-like cell line, RAW264 cells express RANK at high levels, and are differentiated into osteoclasts after stimulation with RANKL . reading wandWebJan 16, 2013 · Mx1-Cre–induced deletion of Ctsk in hematopoietic cells and osteoclasts increased osteoclast differentiation from BM macrophages (BMMs) (Figure 6, ... reading warehouse tadleyWebMay 7, 2024 · After knockout of Ctsk, the gene encoding Ctsk, the outcomes of Ctsk +/+ and Ctsk −/− mice were compared 24 h after rtPA-treated cerebral ischaemia with respect to HT severity, neurological deficits, brain oedema, infarct volume, number of apoptotic neurons and activated microglia/macrophage, blood–brain barrier integrity, vascular ... how to switch long light bulbWebOct 1, 2001 · Cathepsin K (Ctsk) produced by osteoclasts, Cathepsin B (Ctsb) produced by septoclasts, macrophages, and osteoclasts, and immunostaining for the pan … how to switch llc to different stateWebApr 13, 2024 · On day 5, the expression of nuclear factor of activated T cell 1 (NFATc1), acid phosphatase 5 (Acp5), cathepsin K (Ctsk) and matrix metalloprotein 9 (Mmp9), marker genes of osteoclast activity ... how to switch llc to s corpWebSep 22, 2024 · Fig. 7: High expression of CTSK is related to high enrichment of M2 macrophages of tumor-associated in CRPC. A – D IF assay analysis of the correlation … reading wall lights uk