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Interferon regulatory factor family influences tumor immunity …
WebIRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate … WebIRF3 and IRF7 share some structural and functional similarities, but they hold widely distinct roles in the systemic response to infection. While the expression of IRF7 requires the previous activation of IRF3 in most cell types, it is ubiquitously and constitutively expressed in plasmacytoid dendritic cells (pDCs), a rare DC subtype that plays a pivotal role in … cubed chess
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WebJan 20, 2024 · IRF7 activation was induced in pancreatic pDCs in experimental AIP. siRNA-mediated knockdown of IRF7 expression prevented AIP development, which was accompanied by a marked reduction in both pancreatic accumulation of pDCs and production of IFN-α and IL-33. ... (Abcam), IRF7 (Abcam), and Lamin A/C (CST), … WebThe activations of TRIM21, ERK, p-ERK, AP-1, IL-6, TRIB2, IRF3, and IRF7 were detected using western blot. The results clarified that TRIM21 overexpression significantly elevated the p- ERK, c-fos, c-jun, IL-6 and TRIB2 levels in H9 cells (P<0.01, P<0.001), however, remarkably inhibited the levels of IRF3 and IRF7 (P<0.05). WebApr 14, 2011 · IRF7 is activated by pathogenic nuclei acids through pathways mediated by TLR3, -7 and -9, RIG-I and likely DNA-dependent … eastchester recreation department