WebMay 21, 2024 · FOXO3a is a member of the FOXO transcription factor family, which plays a pivotal role in maintaining redox balance. Activation of the SIRT1/FOXO3a pathway can inhibit oxidative stress primarily by regulating antioxidant enzymes [ [13], [14], [15] ]. WebFOXO3a is a transcription factor of the FOXO family. The FOXO proteins participate in multiple signaling pathways, and their transcriptional activity is regulated by several post …
Introduction to FOXO Biology - PubMed
WebDec 1, 2016 · For example, FoxO3a activates FasL transcription, the ligand for the Fas-dependent cell death pathway or pro-apoptotic Bim gene and initiates apoptosis. FoxO3a also induces the expression of cell cycle progression inhibitors including p27 and CyclinD1, thus stalling the G1/S phase transition . Here, we investigated whether the survival … WebThe FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA … photo color software
Crystal structure of the human FOXO3a-DBD/DNA complex …
WebFOXO3a were positively correlated, and both were associated with longer sur-vival in lung cancer patients. Conclusion: Overall, the present study is the first to show that Adjudin syner-gizes with paclitaxel and inhibits cell growth and metastasis by regulating the SIRT3–FOXO3a axis in SCLC; thus, Adjudin has great potential to be an anti- Gopinath et al. (2014) demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling pathway (an essential regulator of quiescence in adult stem cells) in the self-renewal of stem cells during muscle regeneration. It is thought that FOXO3a is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD. Ron DePinho's group generated Foxo3 knockout mic… WebNov 15, 2016 · Besides, FoxO3a can trigger apoptosis by promoting the expressions of death receptor ligands in the extrinsic apoptotic pathway, such as Fas ligand 33 and tumor-necrosis-factor-related apoptosis ... photo color shift