Cisplatin kidney injury

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August undefined, 2024

WebNational Center for Biotechnology Information WebIntroduction. Cisplatin is an extensively used chemotherapeutic drug for various types of human cancer. However, 20–35% of patients are diagnosed with renal dysfunction after cisplatin intervention, even after hydration pretreatment. 1 Acute kidney injury (AKI) is the primary manifestation of cisplatin-induced nephrotoxicity. The mechanisms include DNA …

Cisplatin-Induced Rodent Model of Kidney Injury ... - Hindawi

WebSep 1, 2024 · Iron might play a critical role in mediating cisplatin-induced kidney injury; however, the association between CIN and ferroptosis remains unclear. In this study, we found that cisplatin induced an increase in renal iron content and that this effect could be prevented by a ferroptosis inhibitor. 2. Materials and methods WebFeb 1, 2024 · Cis-diamminedichloroplatinum (cisplatin) is an effective agent for treating solid tumors. However, its clinical use is limited by its serious toxic side effects; nephrotoxicity is the most common... darwin harbour water quality objectives

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WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … bit by a copperhead snake

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WebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly . darwin harbour cruises darwinWebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … bit by a copperhead

"WebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ... " - Cisplatin kidney injury

Cisplatin kidney injury

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebMay 8, 2024 · Key Points español 中文 (chinese) . Question What are the characteristics and risk factors associated with acute kidney injury among children receiving cisplatin infusions?. Findings In this cohort study of … WebDec 21, 2024 · Acute kidney injury (AKI) is an ominous clinical–pathologic state associated with the abrupt loss of renal functions and consequential complications. It is estimated that more than 20–50% of hospitalized patients are affected by various episodes of AKI [ 1 ].

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WebWhile the pathogenesis of cisplatin-induced kidney injury is complex, the major underlying mechanisms converge on oxidative stress, inflammation, and renal fibrosis [ 11, 17 ], which may involve major NAD + -dependent redox enzymes, such as mitochondrial complex I, CD38, NNT, NADK, PARP, alpha-keto acid dehydrogenases, and sirtuins. WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal diseases is still unclear and effective treatments are still lacking. DNA damage and the related DNA damage response (DDR) have been confirmed as common pathogenesis of acute …

WebMar 20, 2024 · Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment. Methods This was a … WebFeb 18, 2024 · Decades of research have resulted in significant insight into the pathogenesis of cisplatin-induced AKI, including tubular cell injury and death, vascular damage, oxidative stress, and an...

WebApr 8, 2024 · Acute kidney injury (AKI) comprises a group of clinical syndromes characterized by the sudden or continued decrease of renal function as shown by rapidly increased serum creatinine and reduced estimated glomerular filtration rates ( 1 ). AKI usually happens in hospitalized patients with high morbidity and mortality. WebSep 1, 2004 · Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity. Clin Pharmacol Ther. 2024 04; 101 (4):510-518. PMID: 28002630. View in: PubMed George B, You D, Joy MS, Aleksunes LM. Xenobiotic transporters and kidney injury. Adv Drug Deliv Rev. 2024 07 …

WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as injury to the renal vasculature, results in vasoconstriction, reduced blood flow, and ischemic injury.

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … bit by a cougarWebMar 27, 2024 · Cisplatin causes tubular damage and acute kidney injury (AKI) [ 10, 11 ]. Although AKI is a long-term risk factor for chronic kidney disease and death [ 12, 13 ], no clinical studies have examined the association between cisplatin-induced AKI (c-AKI) and postoperative complications. darwin harbour wave pool1. Introduction. Acute kidney injury (AKI) is defined as a clinical syndrome … bit by a dead bee lyricsWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney … darwin harbour fishing charters reviewsWebPatients who receive a single dose of cisplatin may suffer from reversible kidney injury, while large doses or multiple courses of treatment may cause irreversible renal failure . bit by a cougar lyricsWebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... bit by a dead bee pt 1 lyricsWebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … bit by a dead bee