Cisplatin induced aki
WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to … WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD).
Cisplatin induced aki
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WebApr 6, 2015 · Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. The initial injury triggers a proliferative response in renal tubular cells, which in the presence of cellular damage can further accelerate renal injury. WebApr 25, 2014 · After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11]. An improved knowledge of the …
WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … WebMay 18, 2024 · The incidence of cisplatin-induced AKI in elderly patients was significantly higher than that of cisplatin-induced renal toxicity partly because three of the included studies defined AKI as a 25% increase in baseline creatinine, one as 20% reduction in Ccr, and two as a 0.3–0.4 mg/dl increase in baseline creatinine, which is more sensitive than …
WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction (Fig. 1 A–C).Total iron content and TfR and FTH protein expression were … WebAug 1, 2024 · A mouse model of cisplatin-induced AKI was established as described previously. After 10 mg/kg cisplatin (Sigma-Aldrich, USA, P4394) intraperitoneal injection for 72 h, Neu-NVs, hucMSC-sEVs, and NEX with the same particle number were administered to the AKI mice by tail vein for 2 consecutive days.
WebFeb 3, 2024 · Cisplatin, a widely used anticancer agent, can cause nephrotoxicity, including both acute kidney injury (AKI) and chronic kidney diseases, by accumulating in renal tubular epithelial cells (TECs). Mitochondrial pathology plays an important role in the pathogenesis of AKI. Based on the regulatory role of transcription factor EB (TFEB) in …
WebOther pathogenic factors such as FA, oxalate, cisplatin, and gentamicin can also promote the occurrence of Fenton-like chemistry, induce ferroptosis, and lead to AKI. The Fenton-like chemistry can be inhibited by intracellular GPX4, a … crystalis switchWebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease. dwight heathWebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at … crystalis walkthrough ignWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … crystalis treasures herndon vaWebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … crystal is uvc ledWebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin-induced acute kidney injury (AKI) remain elusive, despite many investigations that were devoted to this subject matter over a period of decades. crystal is uvcWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … crystalis warrior ring